My paper on Hamilton’s Rule with Jason Wolf, Butch Brodie, and Allen Moore was published in Philosophical Transactions of the Royal Society B as part of a special issue on inclusive fitness. We review several different ways that Hamilton’s rule, which predicts whether altruism should evolve, has been incorporated into the standard quantitative genetic model of evolution. We distill a lot of mathematical theory down into what I hope is a fairly readable account of some pretty complex models!